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Strains

Bifidobacterium lactis DSM 15954

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Isolated:

1980s

Unique feature:

Ability to enhance mucosal immunity.

Clinical Research:

200+ human trials

Health areas:

Immunity, bowel regularity and constipation

What is Bifidobacterium lactis DSM 15954?

Based on publicly available information, the Bifidobacterium lactis DSM 15954 strain is genetically identical to the more commonly known strain Bifidobacterium lactis BB-12®¹.

BB-12® is one of the most extensively studied probiotic strains worldwide². First isolated in the 1980s, it had already been investigated in more than 130 human clinical trials by 2014³, and more recent summaries indicate that the number of studies now exceeds 200⁴.

A distinctive feature of BB-12® is its ability to produce acetate and lactate, compounds that help shape the gut environment by lowering pH and providing fuel for other beneficial microbes⁵. It is also a naturally occurring member of the infant gut microbiome, particularly in breastfed babies³.

Scientific Research: BB-12

BB-12® has been studied in human trials investigating areas such as bowel regularity, constipation, diarrhoea, and immunity. Research consistently demonstrates its excellent safety profile across a wide range of groups, including preterm babies, infants and older adults. You can explore a selection of these publications in our research library.

Where You’ll Find It

BB-12® has been widely used in infant formulas, dietary supplements, and fermented milk products across the world. However, in multi-strain supplements it is often included at a dose lower than the dose studied in the clinical trials.

At Evidose, we include Bifidobacterium lactis DSM 15954 (identical to BB-12®) in our Live Biotic Daily+ formula, at a dose consistent with those used in published research.

References

1. Jensen K, Al-Nakeeb K, Koza A, Zeidan AA.2021.Updated Genome Sequence for the Probiotic Bacterium Bifidobacterium animalis subsp. lactis BB-12. Microbiol Resour Announc10:10.1128/mra.00078-21.https://doi.org/10.1128/mra.00078-21

2. Collins FWJ, Vera-Jiménez NI, Wellejus A. Understanding the probiotic health benefits of Bifidobacterium animalis subsp. lactis, BB-12™. Front Microbiol. 2025 Jul 2;16:1605044. doi: 10.3389/fmicb.2025.1605044. PMID: 40673154; PMCID: PMC12265310.

3. Jungersen M, Wind A, Johansen E, Christensen JE, Stuer-Lauridsen B, Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014 Mar 28;2(2):92-110. doi: 10.3390/microorganisms2020092. PMID: 27682233; PMCID: PMC5029483.

4. Novonesis. New landmark scientific review of BB-12® probiotic strain published. July 2025.
https://www.novonesis.com/en/news/new-landmark-scientific-review-bb-12-probiotic-strain-published

5. Mohan R, Koebnick C, Schildt J, Mueller M, Radke M, Blaut M. Effects of Bifidobacterium lactis Bb12 supplementation on body weight, fecal pH, acetate, lactate, calprotectin, and IgA in preterm infants. Pediatr Res. 2008 Oct;64(4):418-22. doi: 10.1203/PDR.0b013e318181b7fa. PMID: 18552710.