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Strains studied in 500+ clinical trials.
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| Ingredient | Year | Scientific publication |
|---|---|---|
| Lactobacillus Acidophilus NCFM | 1997 | Gilliland SE, Speck ML. Antagonistic Action of Lactobacillus acidophilus Toward Intestinal and Foodborne Pathogens in Associative Cultures 1. J Food Prot. 1977 Dec;40(12):820-823. doi: 10.4315/0362-028X-40.12.820. PMID: 30736216. |
| Lactobacillus Rhamnosus GG | 1999 | Alander M et al., Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption. Appl Environ Microbiol. 1999 Jan;65(1):351-4. doi: 10.1128/AEM.65.1.351-354.1999. PMID: 9872808; PMCID: PMC91031. |
| Lactobacillus Rhamnosus GG | 1999 | Arvola T et al., Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study. Pediatrics. 1999 Nov;104(5):e64. doi: 10.1542/peds.104.5.e64. PMID: 10545590. |
| Lactobacillus Rhamnosus GG | 2000 | Guandalini S et al., Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial. J Pediatr Gastroenterol Nutr. 2000 Jan;30(1):54-60. doi: 10.1097/00005176-200001000-00018. PMID: 10630440. |
| Lactobacillus Rhamnosus GG | 2000 | Chiang BL et al., Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses. Eur J Clin Nutr. 2000 Nov;54(11):849-55. doi: 10.1038/sj.ejcn.1601093. PMID: 11114680. |
| Bifidobacterium Lactis HN019 | 2000 | Gill HS et al., Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Br J Nutr 83: 167-176. 2000. https://doi.org/10.1017/s0007114500000210 |
| Lactobacillus Acidophilus NCFM | 2001 | Sanders ME et al., Invited review: the scientific basis of Lactobacillus acidophilus NCFM functionality as a probiotic. J Dairy Sci. 2001 Feb;84(2):319-31. doi: 10.3168/jds.S0022-0302(01)74481-5. PMID: 11233016. |
| Bifidobacterium Lactis HN019 | 2001 | Gill HS et al., Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am J Clin Nutr. 2001 Dec;74(6):833-9. doi: 10.1093/ajcn/74.6.833. PMID: 11722966. |
| Bifidobacterium Lactis HN019 | 2001 | Shu Q and Gill HS., A dietary probiotic (Bifidobacterium lactis HN019) reduces the severity of Escherichia coli 0157:H7 infection in mice. Med Microbiol Immunol, 2001, 189: 147- 152. https://doi.org/10.1007/s430-001-8021-9 |
| Lactobacillus Rhamnosus GG | 2004 | Yan F, Polk DB. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem. 2002 Dec 27;277(52):50959-65. doi: 10.1074/jbc.M207050200. Epub 2002 Oct 21. PMID: 12393915; PMCID: PMC4006994. |
| Bifidobacterium Lactis HN019 | 2005 | Gopal et al., Effects of the consumption of Bifidobacterium lactis HN019 (DR10 TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutrition Research - NUTR RES. 23. 1313-1328, 2003. |
| Lactobacillus Acidophilus NCFM | 2007 | Azcarate-Peril MA et al., Identification and inactivation of genetic loci involved with Lactobacillus acidophilus acid tolerance. Appl Environ Microbiol. 2004 Sep;70(9):5315-22. doi: 10.1128/AEM.70.9.5315-5322.2004. PMID: 15345415; PMCID: PMC520879. |
| Lactobacillus Acidophilus NCFM | 2008 | Altermann E et al., Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):3906-12. doi: 10.1073/pnas.0409188102. Epub 2005 Jan 25. PMID: 15671160; PMCID: PMC554803. |
| Lactobacillus Acidophilus NCFM | 2005 | Azcarate-Peril MA et al., Microarray analysis of a two-component regulatory system involved in acid resistance and proteolytic activity in Lactobacillus acidophilus. Appl Environ Microbiol. 2005 Oct;71(10):5794-804. doi: 10.1128/AEM.71.10.5794-5804.2005. PMID: 16204490; PMCID: PMC1266013. |
| Bifidobacterium Lactis HN019 | 2007 | Ahmed M et al., Impact of consumption of different levels of Bifidobacterium lactis HN019 on the intestinal microflora of elderly human subjects. J Nutr Health Aging. 2007 Jan-Feb;11(1):26-31. PMID: 17315077. |
| Lactobacillus Acidophilus NCFM | 2008 | Konstantinov SR et al., S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions.(2008) PNAS 105: 19473-19478. |
| Lactobacillus Rhamnosus GG | 2009 | Kankainen M et al., Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17193-8. doi: 10.1073/pnas.0908876106. Epub 2009 Sep 17. PMID: 19805152; PMCID: PMC2746127. |
| Lactobacillus Rhamnosus GG | 2010 | Hojsak I et al., Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clin Nutr. 2010 Jun;29(3):312-6. doi: 10.1016/j.clnu.2009.09.008. Epub 2009 Nov 5. PMID: 19896252. |
| Lactobacillus Rhamnosus GG | 2010 | Hojsak I et al., Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics. 2010 May;125(5):e1171-7. doi: 10.1542/peds.2009-2568. Epub 2010 Apr 19. PMID: 20403940. |
| Bifidobacterium Lactis HN019 | 2010 | Liu C, et al., Adhesion and immunomodulatory effects of Bifidobacterium lactis HN019 on intestinal epithelial cells INT-407. World J Gastroenterol, 2010, 16: 2283-2290. https://doi.org/10.3748/wjg.v16.i18.2283 |
| Bifidobacterium Lactis DSM 15954 (BB-12) | 2010 | Taipale T et al., Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy. Br J Nutr. 2011 Feb;105(3):409-16. doi: 10.1017/S0007114510003685. Epub 2010 Sep 24. PMID: 20863419. |
| Lactobacillus Rhamnosus GG | 2011 | Von Ossowski I et al., Functional characterization of a mucus-specific LPXTG surface adhesin from probiotic Lactobacillus rhamnosus GG. Appl Environ Microbiol. 2011 Jul;77(13):4465-72. doi: 10.1128/AEM.02497-10. Epub 2011 May 20. PMID: 21602388; PMCID: PMC3127685. |
| Bifidobacterium Lactis HN019 | 2011 | Waller PA et al., Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. Scand J Gastroenterol. 2011 Sep;46(9):1057-64. doi: 10.3109/00365521.2011.584895. Epub 2011 Jun 13. PMID: 21663486; PMCID: PMC3171707. |
| Bifidobacterium Lactis DSM 15954 (BB-12) | 2011 | Kabeerdoss J et al., Effect of yoghurt containing Bifidobacterium lactis Bb12® on faecal excretion of secretory immunoglobulin A and human beta-defensin 2 in healthy adult volunteers. Nutr J. 2011 Dec 23;10:138. doi: 10.1186/1475-2891-10-138. PMID: 22196482; PMCID: PMC3265429. |
| Bifidobacterium Lactis DSM 15954 (BB-12) | 2012 | Rizzardini G et al., Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study. Br J Nutr. 2012 Mar;107(6):876-84. doi: 10.1017/S000711451100420X. Epub 2011 Sep 7. PMID: 21899798. |
| Lactobacillus Rhamnosus GG & Bifidobacterium Lactis DSM 15954 (BB-12) | 2013 | Smith TJ et al., Effect of Lactobacillus rhamnosus LGG® and Bifidobacterium animalis ssp. lactis BB-12® on health-related quality of life in college students affected by upper respiratory infections. British Journal of Nutrition. 2013;109(11):1999-2007. doi:10.1017/S0007114512004138 |
| Lactobacillus Acidophilus NCFM | 2014 | Ringel-Kulka T et al., Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study. Aliment Pharmacol Ther. 2014 Jul;40(2):200-7. doi: 10.1111/apt.12800. Epub 2014 May 22. PMID: 24853043; PMCID: PMC4613798. |
| Lactobacillus Acidophilus NCFM & Bifidobacterium Lactis HN019 | 2014 | Magro, D.O. et al., Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J 13, 75 (2014). https://doi.org/10.1186/1475-2891-13-75 |
| Bifidobacterium Lactis DSM 15954 (BB-12) | 2014 | Jungersen M et al., The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014 Mar 28;2(2):92-110. doi: 10.3390/microorganisms2020092. PMID: 27682233; PMCID: PMC5029483. |
| Lactobacillus Rhamnosus GG | 2015 | Szajewska H, Kołodziej M. Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults. Aliment Pharmacol Ther. 2015 Nov;42(10):1149-57. doi: 10.1111/apt.13404. Epub 2015 Sep 13. PMID: 26365389. |
| Bifidobacterium Lactis DSM 15954 (BB-12) | 2015 | Eskesen D et al., Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutr. 2015 Nov 28;114(10):1638-46. doi: 10.1017/S0007114515003347. Epub 2015 Sep 18. PMID: 26382580; PMCID: PMC4657032. |
| Lactobacillus Acidophilus NCFM | 2016 | Lyra A et al., Irritable bowel syndrome symptom severity improves equally with probiotic and placebo. World J Gastroenterol. 2016 Dec 28;22(48):10631-10642. doi: 10.3748/wjg.v22.i48.10631. PMID: 28082816; PMCID: PMC5192275. |
| Bifidobacterium Lactis DSM 15954 (BB-12) | 2016 | Taipale, T., Pienihäkkinen, K., Isolauri, E. et al. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood. Pediatr Res 79, 65–69 (2016). https://doi.org/10.1038/pr.2015.174 |
| Bifidobacterium Lactis DSM 15954 (BB-12) | 2016 | Meng H et al., Consumption of Bifidobacterium animalis subsp. lactis BB-12 impacts upper respiratory tract infection and the function of NK and T cells in healthy adults. Mol Nutr Food Res. 2016 May;60(5):1161-71. doi: 10.1002/mnfr.201500665. Epub 2016 Mar 1. PMID: 26821116. |
| Lactobacillus Rhamnosus GG | 2017 | Ouwehand AC. A review of dose-responses of probiotics in human studies. Benef Microbes. 2017 Apr 26;8(2):143-151. doi: 10.3920/BM2016.0140. Epub 2016 Dec 23. PMID: 28008787 |
| Bifidobacterium Lactis HN019 | 2017 | Miller LE et al., The Effect of Bifidobacterium animalis ssp. lactis HN019 on Cellular Immune Function in Healthy Elderly Subjects: Systematic Review and Meta-Analysis. Nutrients. 2017 Feb 24;9(3):191. doi: 10.3390/nu9030191. PMID: 28245559; PMCID: PMC5372854. |
| Bifidobacterium Lactis HN019 | 2017 | Dalziel JE et al., Promotility action of the probiotic Bifidobacterium lactis HN019 extract compared with prucaloprine in isolated rat large intestine. Front Neurosci, 2017, 11: 20. https://doi.org/10.3389/fnins.2017.00020 |
| Bifidobacterium Lactis HN019 | 2018 | Ibarra A et al., Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial. Gut Microbes. 2018;9(3):236-251. doi: 10.1080/19490976.2017.1412908. Epub 2018 Feb 8. PMID: 29227175; PMCID: PMC6219592. |
| Lactobacillus Acidophilus NCFM | 2019 | Wang H et al., Surface-layer protein from Lactobacillus acidophilus NCFM attenuates tumor necrosis factor-α-induced intestinal barrier dysfunction and inflammation.(2019) Int J Biol Macromol 136: 27–34. https://doi.org/10.1016/j.ijbiomac.2019.06.041 |
| Lactobacillus Rhamnosus GG | 2020 | Sanborn V et al., Randomized Clinical Trial Examining the Impact of Lactobacillus rhamnosus GG Probiotic Supplementation on Cognitive Functioning in Middle-aged and Older Adults. Neuropsychiatr Dis Treat. 2020 Nov 13;16:2765-2777. doi: 10.2147/NDT.S270035. PMID: 33223831; PMCID: PMC7671471. |
| Lactobacillus Acidophilus NCFM | 2021 | Goh YJ et al., In vivo transcriptome of Lactobacillus acidophilus and colonization impact on murine host intestinal gene expression.(2021) mBio 12: e03399-20. https://doi.org/10.1128/mBio.03399-20 |
| Bifidobacterium Lactis DSM 15954 (BB-12) | 2021 | Merenstein, D et al., Bifidobacterium animalis subsp. lactis BB-12 Protects against Antibiotic-Induced Functional and Compositional Changes in Human Fecal Microbiome. Nutrients, 13(8), 2814., 2021, https://doi.org/10.3390/nu13082814 |
| Bifidobacterium Lactis DSM 15954 (BB-12) | 2021 | Chen K et al., Efficacy of Bifidobacterium animalis subsp. lactis, BB-12® on infant colic - a randomised, double-blinded, placebo-controlled study. Benef Microbes. 2021 Nov 16;12(6):531-540. doi: 10.3920/BM2020.0233. Epub 2021 Sep 22. PMID: 34550055. |
| Bifidobacterium Lactis DSM 15954 (BB-12) | 2021 | Harata, G. et al., Species- and Age/Generation-Dependent Adherence of Bifidobacterium bifidum to Human Intestinal Mucus In Vitro. Microorganisms, 9(3), 542. 2021, https://doi.org/10.3390/microorganisms9030542 |
| Lactobacillus Acidophilus NCFM | 2022 | Gao H, Li X et al., The Functional Roles of Lactobacillus acidophilus in Different Physiological and Pathological Processes. J Microbiol Biotechnol. 2022 Oct 28;32(10):1226-1233. doi: 10.4014/jmb.2205.05041. Epub 2022 Aug 30. PMID: 36196014; PMCID: PMC9668099. |
| Lactobacillus Rhamnosus GG | 2022 | Steele, C. (2022) Lactobacillus rhamnosus GG: a review of clinical use and efficacy. Nutr. Med. J., 1 (3), 70-116. |
| Bifidobacterium Lactis HN019 | 2022 | Dekker J et al., Comparison of two probiotics in follow-on formula: Bifidobacterium animalis subsp. lactis HN019 reduced upper respiratory tract infections in Chinese infants. Benef Microbes. 2022 Oct 4;13(4):341-354. doi: 10.3920/BM2022.0041. Epub 2022 Aug 25. PMID: 36004715. |
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Use this content to share information about your store and products.
| Ingredient | Year | Scientific publication |
|---|---|---|
| Vitamin D3 | 2000 | Pludowski P et al., Vitamin D Supplementation: A Review of the Evidence Arguing for a Daily Dose of 2000 International Units (50 µg) of Vitamin D for Adults in the General Population. Nutrients. 2024 Jan 29;16(3):391. doi: 10.3390/nu16030391. PMID: 38337676; PMCID: PMC10857599. |
| Vitamin D3 | 2017 | Martineau AR et al., Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017 Feb 15;356:i6583. doi: 10.1136/bmj.i6583. PMID: 28202713; PMCID: PMC5310969. |
| Vitamin D3 | 2020 | Abboud M et al., The Health Effects of Vitamin D and Probiotic Co-Supplementation: A Systematic Review of Randomized Controlled Trials. Nutrients. 2020 Dec 30;13(1):111. doi: 10.3390/nu13010111. PMID: 33396898; PMCID: PMC7824176. |
| Vitamin D3 | 2021 | Pagnini C et al., Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease. Front Pharmacol. 2021 Nov 24;12:747856. doi: 10.3389/fphar.2021.747856. PMID: 34899302; PMCID: PMC8657408. |
| Vitamin D3 | 2023 | Przewłócka K et al., Combined probiotics with vitamin D3 supplementation improved aerobic performance and gut microbiome composition in mixed martial arts athletes. Front Nutr. 2023 Oct 11;10:1256226. doi: 10.3389/fnut.2023.1256226. PMID: 37885441; PMCID: PMC10599147. |
| Vitamin D3 | 2023 | Dědečková E et al., Vitamin D3 Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals. Life (Basel). 2023 Mar 16;13(3):808. doi: 10.3390/life13030808. PMID: 36983963; PMCID: PMC10053989. |
| Vitamin D3 | 2023 | Giustina A et al., Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows. Endocr Rev. 2024 Sep 12;45(5):625-654. doi: 10.1210/endrev/bnae009. PMID: 38676447; PMCID: PMC11405507. |
| Vitamin D3 | 2024 | Tirani SA et al., Effects of probiotic and vitamin D co-supplementation on clinical symptoms, mental health, and inflammation in adult patients with migraine headache: a randomized, triple-blinded, placebo-controlled trial. BMC Med. 2024 Oct 11;22(1):457. doi: 10.1186/s12916-024-03684-6. PMID: 39394141; PMCID: PMC11470646. |
| Vitamin D3 | 2024 | S J Franks et al., Modelling the influence of vitamin D and probiotic supplementation on the microbiome and immune response, Mathematical Medicine and Biology: A Journal of the IMA, Volume 41, Issue 4, December 2024, Pages 304–345, https://doi.org/10.1093/imammb/dqae017 |
| Vitamin D3 | 2024 | Zhu H et al., Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial. Am J Clin Nutr. 2025 Jul;122(1):39-47. doi: 10.1016/j.ajcnut.2025.05.003. Epub 2025 May 21. PMID: 40409468; PMCID: PMC12308094. |
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Learn about each beneficial bacteria strain in Live Biotic Daily+
