What is Lactobacillus acidophilus NCFM?

Lactobacillus acidophilus NCFM® is one of the most widely researched strains of L. acidophilus, first isolated in the 1970s. It has been shown to tolerate stomach acid and bile, enabling it to reach the intestines alive¹. NCFM® also demonstrates strong adhesion to the gut lining, a feature studied for its potential role in barrier function and interactions with the wider microbiome².

A distinctive property of NCFM® is its ability to produce the enzyme β-galactosidase, which breaks down lactose³. This has been investigated as one possible way the strain may support lactose digestion.

Scientific Research: NCFM

NCFM® is among the most studied acidophilus strains, with over 370 scientific publications and more than 60 human clinical trials. These studies have examined its interactions with the gut microbiome and the immune system. Research has also explored its use in areas such as lactose digestion, bowel regularity, and in people with irritable bowel syndrome (IBS). You can browse a selection of these publications in our research library.

Where You’ll Find It

NCFM® can be found in some probiotic supplements worldwide, either on its own or in combination with other strains. However, in multi-strain supplements it is often included at a dose lower than the dose studied in the clinical trials.

At Evidose, we include NCFM® in our Live Biotic Daily+ formula at a dose consistent with those used in published research.